Featured · 2026
Dietary fiber reduces mortality from secondary sepsis in a murine model of Clostridioides difficile infection
Apgar M, Wall ES, Midura-Kiela M, Neff CP, Orlicky DJ, Lyon LM, Bernardazzi C, Martin CG, Gordon OM, Jimenez-Espinoza I, Flynn JK, Lozupone CA, Hazleton KZ
iScience. 2026;29(4):115258
Mice fed low-fiber diets showed elevated mortality from CDI, driven by translocation of intestinal pathobionts and secondary sepsis — ameliorated by fiber supplementation, suggesting a protective role for dietary fiber via intestinal barrier function.
Selected Publications
Dietary fat promotes antibiotic-induced Clostridioides difficile mortality in mice
Hazleton KZ, Martin CG, Arnolds KL, Nusbacher NM, Moreno-Huizar N, Armstrong ML, Reisdorph N, Lozupone CA
NPJ Biofilms and Microbiomes. 2022;8(1):15
PubMed: 35365681
Acyclic immucillin phosphonates: second-generation inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase
Hazleton KZ, Ho MC, Cassera MB, Clinch K, Crump DR, Rosario Jr I, Merino EF, Almo SC, Tyler PC, Schramm VL
Chemistry & Biology. 2012;19(6):721-730
PubMed: 22726686
Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model
Cassera MB, Hazleton KZ, Merino EF, Obaldia 3rd N, Ho MC, Murkin AS, DePinto R, Gutierrez JA, Almo SC, Evans GB, Babu YS, Schramm VL
PLoS One. 2011;6(11):e26916
PubMed: 22096507